|
KMID : 0043320110340081389
|
|
Archives of Pharmacal Research
2011 Volume.34 No. 8 p.1389 ~ p.1397
|
|
|
Induction of secretory leukocyte protease inhibitor (SLPI) in estradiol valerate (EV) induced polycystic ovary
|
|
Park Jin-Ju
Bae Chun-Sik
Choi Baik-Dong
Jeong Soon-Jeong
Wang Guan-lin
Lim Do-Seon
Kim Byung-Ock
Cho Young-Sik
Kim Sun-Ju
Jeong Moon-Jin
|
|
|
Abstract
|
|
|
|
The excessive administration of estradiol valerate induces polycystic ovary syndrome by formation of follicular cysts. Secretory leukocyte protease inhibitor (SLPI) promotes wound healing by decreasing the excessive inflammatory response, stimulating keratinocyte proliferation and increasing collagen deposition through the inhibition of protease activity. In this study, SLPI expression was high in the ovarian stroma, corpus luteum, unilaminar primary follicle, multilaminar primary follicle and granulose layer of the antral follicle in polycystic ovary (PCO) compared to the normal ovary. SLPI was expressed strongly in the theca around the cyst in PCO compared to the mature follicle in the normal ovary. The levels of SLPI mRNA and protein expression were higher in PCO than in the normal ovary, and the level of MMP-2 expression was lower in PCO. These results showed that the formation of a cyst was initiated from a multilaminar primary follicle and SLPI expression was increased depending on the morphological changes in the follicle and ovarian stroma. Therefore, an increase in SLPI may be related to the suppression of tissue disruption, and act as a protease inhibitor in PCO, suggesting that SLPI increases independently of the estrogen concentration in pathological tissues.
|
|
|
KEYWORD
|
|
|
SLPI, Estrogen, Estradiol valerate, PCO, MMPs
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|